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Balakumar, B. S.
- DNA Damage by Sodium Arsenite in Experimental Rats: Ameliorative Effects of Antioxidant Vitamins C and E
Abstract Views :484 |
PDF Views:159
Authors
Affiliations
1 Dept. Of Plant biology & Plant Biotechnol., RKM. Vivekananda College, Mylapore, Chennai 600 004, IN
2 Mayo Clinic, Rochester, Minnesota, US
1 Dept. Of Plant biology & Plant Biotechnol., RKM. Vivekananda College, Mylapore, Chennai 600 004, IN
2 Mayo Clinic, Rochester, Minnesota, US
Source
Indian Journal of Science and Technology, Vol 3, No 3 (2010), Pagination: 322-327Abstract
Serious health problems in humans are caused by arsenic-exposure, which is wide spread in the environment. Sodium arsenite, capable of inducing macromolecular damage is evaluated for its DNA damaging effect in the blood, liver, kidney and bone marrow cells of Wistar rats. Also the ameliorative potential of a-tocopherol (400 mg/kg body weight) and ascorbic acid (200 mg/kg body weight) supplemented orally to arsenic-intoxicated rats (100 ppm in drinking water for thirty days) in neutralizing the genotoxic effect of arsenite was explored. Detection of DNA damage at cellular level is evaluated by single cell gel electrophoresis or comet assay, under alkaline conditions. This study demonstrated that dietary supplementation of antioxidants such as vitamins C and E could ameliorate arsenite induced toxicity in experimental rats.Keywords
Arsenic, Antioxidants, Ascorbic Acid, Comet Assay, DNA Damage, Genotoxicity, in vivo, α- TocopherolFull Text
References
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- Clastogenic Effect of Sodium Arsenite in Experimental Rats and Ameliorative Effects of Antioxidant Vitamins C and E
Abstract Views :456 |
PDF Views:119
Authors
Affiliations
1 Department of Plant Biology & Plant Biotechnology, RKM. Vivekananda College, Mylapore, Chennai -600 004, IN
2 Research Institute of Veterinary Medicine, Chungbuk National University, South korea
1 Department of Plant Biology & Plant Biotechnology, RKM. Vivekananda College, Mylapore, Chennai -600 004, IN
2 Research Institute of Veterinary Medicine, Chungbuk National University, South korea
Source
Indian Journal of Science and Technology, Vol 3, No 6 (2010), Pagination: 642-647Abstract
Arsenic, an element ubiquitous in the environment, causes serious health problems in humans. The general population is more exposed to arsenic through drinking water than through air and food. Sodium arsenite, capable of inducing genotoxic effects through oxidative stress, is evaluated for its clastogenic effect by the formation of chromosomal aberrations in the bone marrow cells of Wistar rats. We also investigated whether the oral supplementation of α- tocopherol (400 mg/kg body weight) and ascorbic acid (200 mg/kg body weight) to arsenic-intoxicated rats (100 ppm in drinking water) for 30days, ameliorates arsenic-induced toxicity. We report that the dietary supplementation of antioxidants such as vitamins C and E could prevent sodium arsenite induced toxicity in rats under experimental conditions.Keywords
Arsenic, Genotoxicity, Ascorbic Acid, α-tocopherol, Chromosomal Aberrations, Vitamins, Rat, Bone MarrowFull Text
References
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- Bjorneboe A, Bjornenoe GE and Drevon CA (1990) Absorption, transport and distribution of vitamin E. J. Nutr. 120, 233-242.
- Burton GW, Joycen A and Ingold KU (1983) Is vitamin E the only lipid soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch. Biochem. Biophys. 221, 281-290.
- Cebrian M, Finkelman J, Correy G and Calderon R (1993) Heavy Metals in: Environmental Epidemiology (eds). A project for Latin America and the Caribbean metepec, Mexico: Pan American Centre for Human Ecology and Health, WHO. pp: 95-145.
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- Goyer RA, Cherian MG, Jones MM and Reigart JR (1995) Role of Chelatingagents for prevention, intervention and treatment of experimental toxic agents. Environ. Health Perspect. 105, 1048-1052.
- Gurr JR, Bau DT, Liu F, Lynn S and Jan KY (1999) Dithiothreitol enhances arsenic trioxide induced apoptosis in NB4 cells. Mol. Pharmacol. 56, 102-109.
- Gurr JR, Liu F, Lynn S and Jan KY (1998) Calciumdependent nitric oxide production is involved in arsenite-induced micronulei. Mutat. Res. 416, 137-148.
- Halliwell B (1990) How to characterize a biological antioxidant. Free Radical Res. Commun. 9, 1-32.
- Hei TK and Filipic M (2004) Role of oxidative damage in the genotoxicityof arsenic. Free Radical Biol. Med. 37(5), 574-581.
- Hei TK, Liu SX and Waldren C (1998) Mutagenecity of arsenic in mammalian cells: Role of reactive oxygen species. Proc. Natl. Acad. Sci. 95, 8103-8107.
- Hood RD, Vedel-Macrander GC, Zaworotko MJ, Tatum FM and Meck RG (1987) Distribution, metabolism and fetal uptake of pentavalent arsenic in pregnant mice following oral or intra peritonea administration. Teratology. 35, 19.
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- Kessel M, Liu SX, Xu A, Santella R and Hei TK (2002) Arsenic induces oxidative DNA damage in mammalian cells. Mol. Cell Biochem. 234-235(1-2), 301-308.
- Lee TC, Lee KC, Tzeng YJ, Hung RY and Jan KY (1986) Sodium arsenite potenitates the clastogenicity and mutagenicity of DNA crosslinking agents. Environ. Mutagen. 8, 19-128.
- Lee TC, Tseng SF, Chang YC, Lin KY and Jan MR (1996) Post treatment with sodium arsenite during G2 enhance the frequency of chromosomal aberrations induced by S-dependent clastogens. Mutat. Res. 163, 263-269.
- Liu SX, Davidson MM, Tang X, Walker WF, Athar M, Ivanov V and Hei TK (2005) Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res. 65(8), 3236-3242.
- Luo ZD, Zhang YM, Ma L, Zhang ZY and He L (1997) Chronic arsenicism and cancer in inner Mangolia consequences of well-water arsenic level greater than 50 mu/l. In: Arsenic exposure and health effects (Abernathy co., Claderon RC, Chappell WR, eds.) London: Chapman & Hall. pp:55-68.
- Lynn S, Gurr JR, Lai HT and Jan KY (2000) NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Cir. Res. 86, 514-519.
- Mazumdar DNG, Chakraborty AK, Ghose A, Gupta JD, Chakraborty DP and Dey SB (1988) Chronic arsenic toxicity from drinking water in rural West Bengal. Bull. World Health Org. 66, 499-506.
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- Nishikimi M (1975) Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system. Biochem. Biophys. Res. Commun. 63, 463-468.
- NRC-National Research Council (1999) Chemistry and analysis of arsenic species in water, food, urine, blood, hair and nails. In: Arsenic in drinking water (National Research Council, eds.), National Academy Press, Washington, DC. pp:27-82.
- Okui T and Fujiwara Y (1986) Inhibition of human excision DNA repair by inorganic arsenic and the co-mutagenic effect of C79 Chinese hamster cells. Mutat Res.172, 69-76.
- Osborne ED (1925) Microchemical studies of arsenic in arsenical pigmentation and keratoses. Arch. Dermal Syph. 12, 773.
- Rahman MM, Sengupta MK, Ahamed S, Lodh D, Das B, Hossain MA, Nayak B, Mukherjee A, Chakraborti D, Mukherjee SC, Pati S, Saha KC, Palit SK, Kaies I, Barua AK and Asad KA (2005) Murshidabad-one of the nine groundwater arsenic-affected districts of West Bengal, India. Part I: magnitude of contamination and population at risk. Clin. Toxicol. (Phila). 43(7), 823-834.
- Ramanathan K, Anusuyadevi M, Shila S and Panneerselvam C (2005) Ascorbic acid and alpha tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol. Lett. 156(2), 297-306.
- Rich CH, Biggs ML and Smith AH (1998) Lung and kindey cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Int. J. Epidemiol. 27, 561-569.
- Roy P and Saha A (2002) Metabolism and toxicity of arsenic: A human carcinogen. Curr. Sci. 82(1)38-45.
- Samokyszyn VM, Miller DM, Reif DW and Aust SD (1990) Iron-catalyzed lipid peroxidation. In: Membrane lipid oxidation, Vol. 1(Vigo-Pelfrey C.ed.). Boca Raton, FL: CRC Press. pp:101-127.
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- Shaw WD, Walker M and Benson M (2005) Treating and drinking well water in the presence of health risks from arsenic contamination: results from a U.S. hot spot. Risk Anal. 25(6), 1531-1543.
- Smith AH, Goycolea M, Haque R and Biggs ML (1998) Marked increase in bladder and lung cancer mortality in a region of northern Chile due to arsenic in drinking water. Am. J. Epidemiol. 147, 660-669.
- Stocken LA and Thompson RHS (1946) Arsenic derivaties of thiol proteins. Biochem. J. 40, 548.
- Tseng CH, Huang YK, Huang YL, Chung CJ, YangMH, Chen CJ and Hsuch YM (2006) Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot-disease hyper-endemic villages in Taiwan. Toxicol. Appl. Pharmacol. 211(2), 175.
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- Wang TS and Huang H (1994) Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells, Mutgenesis. 9, 253-257.
- Wei M, Arnold L, Cano M, Cohen SM. (2005) Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicol. Sci. 83(2), 237-245.
- Welch AH, Lico MS and Huges JL (1998) Arsenic in ground water of the western United States. Ground Water. 26, 33-337.
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- Yamauchi H and Fowler BA (1994) Toxicity and metabolism of inorganic and methylated arsenicals. In arsenic in the environment, Part II: Human health and ecosystem effects. Nriagu JO (ed.), Wiley, NY. pp:35-43.